{"id":144065,"date":"2026-10-08T00:28:00","date_gmt":"2026-10-08T07:28:00","guid":{"rendered":"https:\/\/fuentesfidedignas.com.mx\/?p=144065"},"modified":"2026-10-07T12:32:44","modified_gmt":"2026-10-07T19:32:44","slug":"una-variante-genetica-poco-comun-explica-por-que-algunas-personas-fuman-menos-que-otras","status":"publish","type":"post","link":"https:\/\/fuentesfidedignas.com.mx\/index.php\/2026\/10\/08\/una-variante-genetica-poco-comun-explica-por-que-algunas-personas-fuman-menos-que-otras\/","title":{"rendered":"Una variante gen\u00e9tica poco com\u00fan explica por qu\u00e9 algunas personas fuman menos que otras"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><br><strong><em>Un estudio internacional, publicado en Nature Communications y destacado por el m\u00e9dico Eric Topol, identific\u00f3 variantes raras en un gen que disminuyen la dependencia al tabaco. Podr\u00eda abrir una perspectivas para terapias futuras contra la adicci\u00f3n<\/em><\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Un grupo internacional de cient\u00edficos descubri\u00f3 <strong>una relaci\u00f3n directa entre variantes raras de un gen del receptor de nicotina y la reducci\u00f3n del consumo diario de cigarrillos<\/strong>.<a href=\"https:\/\/www.infobae.com\/salud\/ciencia\/2026\/10\/07\/cancer-de-mama-un-estudio-argentino-hallo-una-secuela-en-las-arterias-que-puede-persistir-anos-despues-de-superar-la-enfermedad\/\" target=\"_blank\" rel=\"noopener\"><\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">La investigaci\u00f3n, <a href=\"https:\/\/www.nature.com\/articles\/s41467-026-68825-2\" target=\"_blank\" rel=\"noopener\">difundida<\/a> en la revista <strong>Nature Communications<\/strong>, analiz\u00f3 los genomas de casi 38.000 fumadores y observ\u00f3 que ciertas mutaciones en el gen <strong>CHRNB3<\/strong>, responsable de codificar la subunidad \u03b23 del receptor nicot\u00ednico de acetilcolina en el cerebro, se asocian con una <strong>menor probabilidad de fumar mucho.<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"482\" height=\"1024\" src=\"https:\/\/fuentesfidedignas.com.mx\/wp-content\/uploads\/2026\/10\/image-6-482x1024.png\" alt=\"\" class=\"wp-image-144066\" srcset=\"https:\/\/fuentesfidedignas.com.mx\/wp-content\/uploads\/2026\/10\/image-6-482x1024.png 482w, https:\/\/fuentesfidedignas.com.mx\/wp-content\/uploads\/2026\/10\/image-6-141x300.png 141w, https:\/\/fuentesfidedignas.com.mx\/wp-content\/uploads\/2026\/10\/image-6-768x1632.png 768w, https:\/\/fuentesfidedignas.com.mx\/wp-content\/uploads\/2026\/10\/image-6-723x1536.png 723w, https:\/\/fuentesfidedignas.com.mx\/wp-content\/uploads\/2026\/10\/image-6-600x1275.png 600w, https:\/\/fuentesfidedignas.com.mx\/wp-content\/uploads\/2026\/10\/image-6-376x799.png 376w, https:\/\/fuentesfidedignas.com.mx\/wp-content\/uploads\/2026\/10\/image-6-188x400.png 188w, https:\/\/fuentesfidedignas.com.mx\/wp-content\/uploads\/2026\/10\/image-6-300x637.png 300w, https:\/\/fuentesfidedignas.com.mx\/wp-content\/uploads\/2026\/10\/image-6-696x1479.png 696w, https:\/\/fuentesfidedignas.com.mx\/wp-content\/uploads\/2026\/10\/image-6-171x363.png 171w, https:\/\/fuentesfidedignas.com.mx\/wp-content\/uploads\/2026\/10\/image-6.png 904w\" sizes=\"(max-width: 482px) 100vw, 482px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Este hallazgo, que fue confirmado en personas de ascendencia mexicana, asi\u00e1tica y europea, sugiere la existencia de mecanismos gen\u00e9ticos con <strong>potencial terap\u00e9utico<\/strong> para combatir la adicci\u00f3n al tabaco.<a href=\"https:\/\/www.infobae.com\/salud\/ciencia\/2026\/10\/07\/por-que-la-somnolencia-de-la-tarde-no-es-pereza-ni-culpa-del-almuerzo\/\" target=\"_blank\" rel=\"noopener\"><\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">La participaci\u00f3n de <strong>Veera Rajagopa<\/strong>, primer autor del trabajo y miembro del <strong>Centro de Gen\u00e9tica Regeneron<\/strong> en Estados Unidos, permiti\u00f3 identificar que \u201clos receptores de acetilcolina son prote\u00ednas que se unen a la nicotina en el cerebro y desencadenan cambios en el comportamiento, en las sensaciones de placer y el grado adicci\u00f3n de fumadores\u201d.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">El equipo de Rajagopa secuenci\u00f3 los genomas de <strong>37.897 personas fumadoras<\/strong> incluidas en el <strong>Estudio Prospectivo de Ciudad de M\u00e9xico<\/strong>, en busca de factores que expliquen diferencias individuales en el consumo de tabaco. Entre los resultados m\u00e1s destacados, se detect\u00f3 una variante en el gen <strong>CHRNB3<\/strong> que se relacion\u00f3 con una reducci\u00f3n significativa en el n\u00famero de cigarrillos diarios.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">En detalle, quienes presentaban una o dos copias del gen mutado fumaban entre un 21% y un 78% menos que aquellos con la versi\u00f3n m\u00e1s com\u00fan. Estos efectos fueron m\u00e1s pronunciados en personas de <strong>ascendencia ind\u00edgena mexicana<\/strong>, aunque el mismo patr\u00f3n se observ\u00f3 en <strong>poblaciones japonesas y europeas,<\/strong> donde se identificaron otras variantes con funci\u00f3n similar. Seg\u00fan <strong>Giovanni Coppola<\/strong>, l\u00edder del estudio, \u201cesto quiere decir que, si bien cada poblaci\u00f3n tiende a tener ciertas variantes \u00fanicas, no existe diferencia entre el gen real o su expresi\u00f3n entre las poblaciones\u201d.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">La investigaci\u00f3n recab\u00f3 datos adicionales del <strong>Biobanco del Reino Unido<\/strong> y el <strong>Biobanco de Jap\u00f3n<\/strong>. All\u00ed, los resultados tambi\u00e9n mostraron que variantes raras de <strong>CHRNB3<\/strong> y de otros genes relacionados con el receptor nicot\u00ednico, como <strong>CHRNB2<\/strong>, se asociaron con una menor dependencia. El an\u00e1lisis de secuenciaci\u00f3n a gran escala, que incluy\u00f3 a m\u00e1s de 150.000 residentes mexicanos, permiti\u00f3 validar la importancia de estas variantes en diferentes contextos geogr\u00e1ficos y gen\u00e9ticos.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Un estudio internacional, publicado en Nature Communications y destacado por el m\u00e9dico Eric Topol, identific\u00f3 variantes raras en un gen que disminuyen la dependencia al tabaco. Podr\u00eda abrir una perspectivas para terapias futuras contra la adicci\u00f3n Un grupo internacional de cient\u00edficos descubri\u00f3 una relaci\u00f3n directa entre variantes raras de un gen del receptor de nicotina [&hellip;]<\/p>\n","protected":false},"author":41,"featured_media":144070,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"tdm_status":"","tdm_grid_status":"","footnotes":""},"categories":[34,36],"tags":[],"class_list":["post-144065","post","type-post","status-publish","format-standard","has-post-thumbnail","category-combate-a-adicciones","category-semanales"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Una variante gen\u00e9tica poco com\u00fan explica por qu\u00e9 algunas personas fuman menos que otras - Fuentes Fidedignas<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fuentesfidedignas.com.mx\/index.php\/2026\/10\/08\/una-variante-genetica-poco-comun-explica-por-que-algunas-personas-fuman-menos-que-otras\/\" \/>\n<meta property=\"og:locale\" content=\"es_MX\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Una variante gen\u00e9tica poco com\u00fan explica por qu\u00e9 algunas personas fuman menos que otras - Fuentes Fidedignas\" \/>\n<meta property=\"og:description\" content=\"Un estudio internacional, publicado en Nature Communications y destacado por el m\u00e9dico Eric Topol, identific\u00f3 variantes raras en un gen que disminuyen la dependencia al tabaco. 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